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. Author manuscript; available in PMC: 2016 Jul 8.
Published in final edited form as: Oncogene. 2015 Oct 26;35(26):3454–3464. doi: 10.1038/onc.2015.405

Figure 1.

Figure 1

Sleeping Beauty mutagenesis screen induces leukemia in Stat5b-CA mice. (a) Flow cytometry of bone marrow from Cd79a-CrexSB and Stat5b-CAxSB control mice versus Stat5b-CAxCd79a-CrexSB leukemic mice, showing efficient deletion of GFP in B lineage cells. (b), Kaplan-Meier survival analysis of mice comparing Stat5b-CAxCd79a-Crex SB(n=80) to control miceCd79a-CrexSB(n=31). (c) Pictures display a comparison of lymph node and spleen from Cd79a-Cre andStat5b-CA control mice and Stat5b-CAxCd79a-CrexSB tumor mice. (d), Flow cytometric analysis of lymph node cells from C57Bl/6 control mice and Stat5b-CAxCd79a-CrexSB tumor mice. Representative flow cytometric analysis of B220, GFP, CD19, BP-1, CD43 (S7), and IgM expression on lymph node cells is shown. Doublets were gated out and a lymphocyte gate was set based on side and forward scatter properties. All gates shown are based on cells from control animals.