Fig. 1.

Schematic display of experimental procedure for miR-124a-induced neurogenesis in vivo. Complexation between negatively charged miR-124a oligomer and positively charged in vivo PEI polymer was formed at room temperature, and neural progenitor cells were mixed with this pre-formed complex polymer before cell implantation. Temperature-sensitive matrigel was used to trap the cells within gel scaffold, and this cell/matrigel complex was implanted into the thighs of nude mice