Fig. 1.

Photomicrographs of immunohistochemical staining for GRP78 in normal and cancerous tissues of colon. a Immunostaining of normal colon tissue: immunoreactivity score (IRS) = 3. b, c Moderately- differentiated tissue sample, stage II disease with 78 % of cells positive (IRS) = 26. d, e Poorly- differentiated tissue sample, stage III disease with 89 % of cells positive (IRS) = 38. f. Metastatic tissue to lung, stage IV disease with 100 % of cells positive (IRS) = 40. All original magnifications, ×400