Table 1.

Minimal inhibitory concentration ranges (μg/ml) and MIC₅₀ and MIC₉₀ ranges for various antimicrobials against M. bovis^a.

Antimicrobials	MICb Range	MIC50 Range	MIC90 Range
Tetracyclines
Tetracycline	< 0.03–>64	1–8	4–64
Oxytetracycline	0.05–128	2–128	4–128
Chlortetracycline	0.25–256	2–128	2–256
Doxycycline	≤ 0.03–1	0.5	1
MLSK Group
Erythromycin	4–>512	>3.2–512	32–512
Tylosin	0.2–>256	1–>128	6.25–>128
Tilmicosin	≤ 0.5–>512	2–512	4–>512
Gamithromycin	128–>128	128	128
Tildipirosin	128–>128	128	128
Tulathromycin	≤ 0.063–>128	0.25–128	8–>64
Kitasamycin	1–128	4	64
Josamycin	0.78–12.5	1.56	6.25
Spiramycin	0.39–>100	3.12	25
Lincomycin	0.06–>256	0.78–>64	3.12–>64
Clindamycin	0.03–>256	0.5–8	>32
Pirlimycin	< 0.125–0.5	0.25	0.5
Pleuromutilins
Tiamulin	< 0.03–2	0.06–0.2	0.78–1
Valnemulin	< 0.03	< 0.03	< 0.03
Fluoroquinolones
Enrofloxacin	0.025–>32	0.12–1	0.12–32
Danofloxacin	0.078–32	0.156–0.5	0.312–8
Marbofloxacin	0.25–>32	0.625–1.25	0.625–32
Flumequine	16–128	64	128
Ciprofloxacin	0.125–1	0.5	1
Aminoglycosides
Gentamycin	2–>64	8	32
Kanamycin	8–>128	32–64	64–>128
Aminocyclitol
Spectinomycin	0.03–>256	1–>256	2–>256
Chloramphenicols/Phenicols
Chloramphenicol	0.25–>32	2–8	2–32
Thiamphenicol	3.12–>512	6.25–>512	12.5–>512
Florfenicol	0.06–64	1–8	2–32

^aThe data are compiled from multiple published studies (Ayling et al., 2000; Hirose et al., 2003; Thomas et al., 2003; Rosenbusch et al., 2005; Godinho, 2008; Gerchman et al., 2009; Uemura et al., 2010; Soehnlen et al., 2011; Kroemer et al., 2012; Hendrick et al., 2013; Ayling et al., 2014; Gautier-Bouchardon et al., 2014; Kawai et al., 2014; Sulyok et al., 2014; Kong et al., 2016) in which different methodologies (microbroth and agar dilution, but not E-test) and different antimicrobial concentrations were used (adapted from Bebear and Kempf, 2005; Waites et al., 2014).

^bOnly MIC data obtained for M. bovis isolated after 1990 were included.