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. 2016 Apr 27;36(17):4802–4815. doi: 10.1523/JNEUROSCI.3186-15.2016

Figure 2.

Figure 2.

Naspm inhibition of EPSCs indicates that in vivo cocaine exposure increases GluA2-lacking AMPARs in Epac+/+ slices but not in Epac−/− slices. A, The selective GluA2-lacking AMPAR blocker Naspm induced greater depression of EPSCs in slices from Epac+/+ mice that received a single cocaine injection compared with those received a single saline injection (***p < 0.001; n = 8 for each group). B, Epac knock-out abrogated the effect of in vivo cocaine injection on Naspm inhibition of EPSCs (p = 0.432; n = 8–9). C, Summarized data showed the effects of NASPM on EPSCs in these four groups (**p = 0.001, n = 8–8; ***p < 0.001, n = 8–8).