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. 2016 Mar 17;33(4):532–552. doi: 10.1007/s12325-016-0315-8

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Molecular structure of LE and its inactive metabolites. LE is a 17β-chloromethylester derivative of Δ1-cortienic acid, an inactive metabolite of prednisolone; LE also has a 17α-etabonate moiety. LE undergoes rapid deesterification to the inactive Δ1-cortienic acid after exerting its effect. LE loteprednol etabonate