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. 2016 Apr 27;6:24854. doi: 10.1038/srep24854

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PRRSV infection downregulates the expression of ssc-miR-30d_R-1 (targets TLR4), which activates the TLR4/MyD88/NF-κB signaling pathway, resulting in promotion of PRRSV replication. Conversely, overexpression of the ssc-miR-30d_R-1 mimic inhibits TLR4, which inhibits the TLR4/MyD88/NF-κB signaling pathway, resulting in reduced PRRSV replication.