Table 3.
Strain | MICs (μg/mL) | ||||||||
---|---|---|---|---|---|---|---|---|---|
AMK | GEN | APR | NEO | CRO | CEF | CEQ | ENR | CIP | |
JS | 0.5 | 0.25 | 2 | 0.4 | 0.02 | 0.32 | 0.08 | 0.032 | 0.016 |
JSΔcpxR | 0.125 | 0.0625 | 1 | 0.1 | 0.01 | 0.08 | 0.04 | 0.032 | 0.016 |
JSΔcpxR/pcpxR | 0.5 | 0.25 | 4 | 0.4 | 0.04 | 0.32 | 0.16 | 0.032 | 0.016 |
JSΔcpxR/pcpxR* | 0.125 | 0.0625 | 1 | 0.1 | 0.01 | 0.08 | 0.16 | 0.032 | 0.016 |
JSΔacrB | 0.25 | 0.25 | 2 | 0.2 | 0.01 | 0.0025 | 0.02 | 0.001 | 0.001 |
JSΔacrBΔcpxR | 0.0625 | 0.0625 | 0.5 | 6.4▴ | 0.01 | 0.00125 | 0.02 | 0.001 | 0.001 |
JSΔacrBΔcpxR/pcpxR | 0.5 | 0.25 | 2 | 25.6▴ | 0.02 | 0.005 | 0.08 | 0.001 | 0.001 |
JSΔacrBΔcpxR/pcpxR▴ | 0.0625 | 0.0625 | 0.5 | 6.4▴ | 0.01 | 0.00125 | 0.04 | 0.001 | 0.001 |
AMK, Amikacin; GEN, Gentamycin; APR, Apramycin; NEO, Neomycin; CRO, Ceftriaxone; CEF, Ceftiofur; CEQ, Cefquinome; ENR, Enrofloxacin; CIP, Ciprofloxacin.
High NEO resistance is present in strains because of the replacement of cpxR gene by kanamycin-resistant gene (ΔcpxR::kan).