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. 2016 Mar 25;8(4):38. doi: 10.3390/cancers8040038

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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H&E (A–D) as well as IHC (E1–E4) stained specimens of four different NET subtypes of the lung. Typical carcinoid (A); atypical carcinoid (B); large cell neuroendocrine carcinoma (C); and small cell lung carcinoma (D) are shown (MiraxDesk scanned). Yellow arrows indicate high mitotic rates. (E1–E4) IHC markers: (E1) LCNEC, MIB-1 analysis (tumor cell proliferation rate); (E2) LCNEC, positive for CD56; (E3) SCLC, positive for synaptophsin; and (E4) LCNEC, positive for chromogranin (MiraxDesk scanned).