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A549 cells were transfected with an empty vector, a construct expressing NORE1A, or NORE1A paired with 5x by mass of a construct expressing MDM2. In A549 cells expressing NORE1A, cells have exhibit a high level of senescence. This effect is suppressed in the presence of over-expressed MDM2. Representative pictures of β-gal staining from 2 independent assays are shown.
