Table 3. Chromosomal locations, positions and biological effects of investigated gene SNPs.
| SNP ID | Gene | TaqMan catalog number | Chr | Chr. Position | Position in the gene/Effect | Codon exchange | aa. exchange |
|---|---|---|---|---|---|---|---|
| rs10434 | VEGF-A | C_1647360_20 | 6 | 43753212 | 3′UTR(c) | – | – |
| rs2010963 | VEGF-A | C_8311614_10 | 6 | 43738350 | 5′UTR(d) | – | – |
| rs25648 | VEGF-A | C_791476_10 | 6 | 43738977 | Syn(a); ESE(b) | TCC ⇒ TCT | S [Ser] ⇒ S [Ser] |
| rs3025039 | VEGF-A | C_16198794_10 | 6 | 43752536 | 3′UTR(c) | – | – |
| rs699947 | VEGF-A | C_8311602_10 | 6 | 43736389 | Prom(e) | – | – |
| rs833061 | VEGF-A | C_1647381_10 | 6 | 43737486 | Prom(e) | – | – |
| rs4604006 | VEGF-C | C_216109_10 | 4 | 177608775 | Intronic | – | – |
| rs7664413 | VEGF-C | C_11780939_10 | 4 | 177608707 | Intronic | – | – |
| rs664393 | VEGFR-1 FLT1 | C_938327_20 | 13 | 29071001 | 3′UTR(c) | – | – |
| rs7993418 | VEGFR-1 FLT1 | C_1910654_10 | 13 | 28883061 | Syn(a); ESE(b) | TAC ⇒ TAT | Y [Tyr] ⇒ Y [Tyr] |
| rs1870377 | VEGFR-2 KDR | C_11895315_20 | 4 | 55972974 | Missense | CAA ⇒ CAT | Q [Gln] ⇒ H [His] |
| rs2071559 | VEGFR-2 KDR | C_15869271_10 | 4 | 55992366 | Init. Transcription | – | – |
| rs2305948 | VEGFR-2 KDR | C_22271999_20 | 4 | 55979558 | Missense | GTA ⇒ ATA | V [Val] ⇒ I [Ile] |
| rs7667298 | VEGFR-2 KDR | C_28992770_10 | 4 | 55991731 | 5′UTR(d) | – | – |
| rs307805 | VEGFR-3 FLT4 | C_918880_10 | 5 | 180077487 | Prom(e); TFBS(g) | – | – |
| rs6877011 | VEGFR-3 FLT4 | C_29057584_10 | 5 | 180029471 | 3′UTR(c) | – | – |
| rs307822 | VEGFR-3 FLT4 | C_918831_1 | 5 | 180028717 | 3′UTR(c) | – | – |
(a)Syn: Synonymous substitution.
(b)ESE: Exon Splicing Enhancer.
(c)3′UTR: Untranslated Region 3′UTR.
(d)5′UTR: Untranslated Region 5′UTR.
(e)Prom: Promoter region.
(g)TFBS: Predicted Trascription Factor Binding Site.