Table 1. Incidence of clinical signs and fecal virus shedding in Gn pigs.
| Group | Time | n | Diarrhea |
Virus shedding |
||
|---|---|---|---|---|---|---|
| Pigs with diarrhea (%)* | Mean duration days (SEM)** | Pigs shedding virus (%)* | Mean duration days (SEM)** | |||
| WT | PID1–3 | 11 | 8 (73%) | 1.0 (0.3) | 9 (82%) | 1.5 (0.3) |
| RAG2/IL2RG deficiency | 12 | 6 (50%) | 0.8 (0.3) | 11 (92%) | 1.3 (0.2) | |
| WT | PID4–10 | 8 | 7 (88%) | 2.8 (0.6) | 7 (88%) | 3.0 (0.7) |
| RAG2/IL2RG deficiency | 9 | 6 (67%) | 1.7 (0.6) | 9 (100%) | 3.4 (0.3) | |
| WT | PID11–17 | 5 | 5 (100%) | 2.6 (1.0) | 2 (40%) | 1.2 (1.0)A |
| RAG2/IL2RG deficiency | 4 | 4 (100%) | 4.5 (1.2) | 4 (100%) | 5.5 (0.6)B | |
| WT | PID18–28 | 5 | 1 (20%) | 0.4 (0.4) | 0A | 0A |
| RAG2/IL2RG deficiency | 4 | 2 (50%) | 0.8 (0.5) | 4 (100%)B | 4.5 (0.3)B | |
Gn pigs were inoculated with a HuNoV GII.4 2006b variant 092895 at 6–7 days of age. Rectal swabs were collected daily after inoculation to determine diarrhea and virus shedding. SEM, standard error of the mean. *Fisher’s exact test or **Mann-Whitney test was used for statistical analysis. Groups with significant differences (P < 0.05) were indicated with letters A and B.