Table 3.
Bone biomechanical strength parameters
| Sham+V | OVX+V | OVX+UDE | OVX+E2 | |
|---|---|---|---|---|
| L5 | ||||
| Ultimate Load (N) | 190.08 ± 18.5 | 104.63 ± 11.47*** | 196.81 ± 6.77 | 168.17 ± 8.05 |
| Energy (mJ) | 248.62 ± 3.24 | 142.34 ± 7.06*** | 258.52 ± 4.57 | 231.68 ± 9.39 |
| Stiffness (N/mm) | 143.28 ± 8.43 | 64.56 ± 5.23*** | 139.75 ± 4.47 | 145.63 ± 7.83 |
| Proximal femur | ||||
| Ultimate Load (N) | 387.4 ± 18.7 | 280.8 ± 13.3*** | 323.2 ± 17.4#,** | 335.8 ± 8.1##,* |
| Energy (mJ) | 490.6 ± 15.6 | 356.0 ± 21.2*** | 400.1 ± 16.5#,** | 406.7 ± 9.3#,* |
| Stiffness (N/mm) | 158.6 ± 3.8 | 78.8 ± 4.9*** | 98.2 ± 3.1#,** | 104.6 ± 5.6#,** |
Data are mean ± SEM (for L5, n = 6 rats/group and for proximal femur, n = 8 rats/group);
*
p<0.05 compared with sham (vehicle treated);
**
p<0.01 compared with sham (vehicle treated);
***
p<0.001 compared with sham (vehicle treated);
#
p<0.05 compared with OVX+vehicle;
##
p<0.01 compared with OVX+vehicle.