Figure 3.

TNF-α (A) and IL-6 (B) levels in lung tissues of 14-day-old rats exposed to prenatal LPS and postnatal RA or hyperoxia and treated with NS or MSCs on Postnatal Day 5. The rats exposed to prenatal LPS and/or postnatal hyperoxia and treated with NS exhibited higher TNF-α and IL-6 levels on Postnatal Day 14. The rats exposed to prenatal LPS and postnatal hyperoxia and treated with MSCs (1×10⁶ cells) exhibited a significantly lower TNF-α level than those treated with NS did. The administration of MSCs (3×10⁵ and 1×10⁶ cells) significantly reduced the IL-6 level in LPS- and hyperoxia-exposed rats than in NS-treated rats. *P < 0.05.