Table 1.

Body weight, kidney and liver function (n=5) in experimental mice

		Wild C57BL/6 mouse					C57BL/6-Tlr4lps-del mouse
	wk
		Normal diet	HC diet				Normal diet	HC diet
		-	-	GroEL 200 μg/kg BW	GroEL 400 μg/kg BW	GST 400 μg/kg BW	-	-	GroEL 400 μg/kg BW
BW (g)	0	24.2±1.0	23.4±0.7	24.2±0.5	22.7±0.4	24.3±2.2	22.6±1.5	22.5±3.1	25.0±1.4
	2	26.6±1.2	24.6±0.2	25.2±0.5	23.2±1.2	26.0±1.5	24.5±1.0	25.3±1.6	25.9±2.5
	4	26.0±0.5	25.1±1.1	27.9±1.1	26.3±1.3	26.4±1.2	25.8±0.9	26.4±2.1	27.4±3.7
BUN (mg/dL)	0	18.5±6.5	21.0±2.2	18.0±4.5	18.3±1.9	17.3±4.4	23.6±1.5	21.5±0.9	27.7±2.9
	2	23.5±3.5	22.3±5.8	18.8±3.5	16.5±1.1	18.3±3.0	22.9±1.0	21.9±2.4	24.0±4.2
	4	20.5±6.5	31.0±12.6	29.3±0.8	24.5±5.5	16.0±7.8	25.0±0.9	19.4±1.9	18.7±5.0
Cr (mg/dL)	0	0.4±0.2	0.8±0.4	0.6±0.2	0.5±0.2	0.6±0.2	0.3±0.1	0.5±0.1	0.8±0.1
	2	0.4±0.2	0.7±0.1	0.7±0.3	0.7±0.2	0.8±0.2	0.5±0.1	0.6±0.1	0.5±0.1
	4	0.8±0.2	0.6±0.2	0.7±0.2	0.6±0.4	0.6±0.2	0.6±0.2	0.7±0.3	0.6±0.2
ALT (IU/L)	0	129.2±4.6	114.5±11.6	113.5±12.2	118.9±9.2	119.9±6.9	124.7±6.2	128.3±5.7	115.0±7.1
	2	101.6±16.9	114.7±9.4	108.4±9.5	120.9±12.6	115.1±8.7	115.3±9.0	100.8±8.5	30.3±4.7
	4	127.5±4.3	118.1±9.8	119.0±4.4	112.8±15.4	126.8±2.7	104.7±5.4	98.4±9.9	30.7±3.8
AST (IU/L)	0	113.4±16.1	89.4±32.0	120.1±35.1	97.1±6.5	111.1±21.9	114.5±5.1	112.4±5.2	117.7±8.5
	2	129.0±2.6	113.4±37.5	115.4±13.6	114.3±20.4	114.7±14.8	108.7±7.8	104.4±4.1	127.1±8.8
	4	111.0±7.2	135.2±38.5	104.8±28.7	125.7±20.7	121.1±18.4	116.0±5.4	112.7±3.5	113.4±7.9
LDH (IU/L)	0	1968.2±863.6	2113.9±306.8	1802.3±452.8	1967.2±896.2	1627.9±73.3	1559.6±107.4	1942.3±196.7	2049.5±106.9
	2	1561.3±110.0	1903.6±321.7	2317.6±639.3	2239.4±219.2	2550.6±313.6	1848.6±289.7	1945.8±366.2	2148.6±520.3
	4	1373.2±248.7	1998.5±316.8	2594.3±249.8	2604.8±152.3	2263.9±652.9	1651.3±176.9	2356.3±508.7	2259.6±421.2

BW, Body weight; HC diet, High cholesterol diet; BUN, blood urea nitrogen; Cr, Creatinine; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase. Values are mean ± SD.