Figure 2.

Treatment with STEA protects against colitis. The recrudescent colitis of rat was induced by twice infusion of TNBS on day 0 (100 mg/kg) and day 18 (10 mg per rat), and rats were administered IP with 3 mg/kg STEA once a day for 5 days after the second infusion of TNBS. Simultaneously, control rats received 40% ethanol infusions and were treated with PB. Clinical evolution was monitored by survival (A) and body weight changes (B). Colitis score (C) and macroscopic damage score (D) were determined at 4 days after TNBS administration. Colonic length (E) was measured from the ileocecal junction to the anal verge at necropsy. (F) Representative histologic findings in rats with TNBS-induced colitis treated with STEA. Sections of the distal colon were collected at necropsy and stained with H&E (original magnification, ×100). Data are expressed as means ± SD, n = 14 rats/group in (A) and (B), n = 5 rats/group in (C) to (E). *p < 0.05 vs TNBS-treated rats; ^p < 0.05 vs control rats.