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. 2016 Feb 15;8(2):778–798.

Table 1.

Transthoracic echocardiographic findings prior to and by day 60 after transverse aortic constriction

Variable Group 1 (n = 10) Group 2 (n = 10) Group 3 (n = 10) Group 4 (n = 10) p-value
Day 0
    IVS thickness (mm) 1.27 ± 0.21 1.28 ± 0.15 1.29 ± 0.19 1.24 ± 0.17 0.526
    PW thickness (mm) 1.19 ± 0.23 1.22 ± 0.22 1.19 ± 0.25 1.21 ± 0.28 0.758
    LVEDD (mm) 7.05 ± 0.82 7.01 ± 0.24 7.01 ± 0.61 7.02 ± 0.92 0.822
    LVESD (mm) 3.84 ± 0.75 3.85 ± 0.25 3.75 ± 0.94 3.76 ± 0.67 0.558
    LVEDV (µL) 335.60 ± 73.90 325.80 ± 90.10 323.70 ± 72.10 329.30 ± 87.40 0.810
    LVESV (µL) 90.40 ± 15.40 91.20 ± 10.70 87.30 ± 19.50 89.30 ± 14.30 0.664
    LVFS (%) 47.92 ± 2.77 46.69 ± 2.43 46.24 ± 3.33 48.69 ± 3.19 0.436
    LVEF (%) 73.52 ± 3.30 72.81 ± 2.70 72.36 ± 2.30 74.78 ± 3.50 0.526
By day 60 after TAC
    IVS thickness (mm) 1.34 ± 0.05a 2.08 ± 0.26b 1.29 ± 0.19 1.87 ± 0.14b,c < 0.001
    PW thickness (mm) 1.20 ± 0.51a 1.57 ± 0.99b 1.19 ± 0.25 1.41 ± 0.24b,c < 0.001
    LVEDD (mm) 7.08 ± 0.12a 7.37 ± 0.74b 7.01 ± 0.61 7.23 ± 0.46c < 0.001
    LVESD (mm) 3.95 ± 0.11a 4.37 ± 0.15b 3.75 ± 0.94 4.24 ± 0.24b < 0.001
    LVEDV (µL) 337.20 ± 33.50a 396.50 ± 21.10b 323.70 ± 72.10 379.40 ± 81.10c < 0.001
    LVESV (µL) 97.00 ± 13.20a 150.10 ± 21.30b 87.30 ± 19.50 136.60 ± 40.30b < 0.001
    LVFS (%) 47.91 ± 1.27a 40.95 ± 2.76b 46.24 ± 3.33 41.46 ± 1.02b < 0.001
    LVEF (%) 72.22 ± 0.90a 62.91 ± 2.30b 72.36 ± 2.30 65.25 ± 1.10d < 0.001

Data are expressed as mean ± SD or %. Group 1 = DPP-4D; Group 2 = DPP-4D + TAC; Group 3 = DPP-4D + TAC + Extendin-4; Group 4 = DPP-4D + TAC + Extendin-4 + EX39-9. Dipeptidyl peptidase-IV deficiency = DPP-4D; LVEDD = left ventricular end-diastolic dimension; LVESD = left ventricular end-systolic dimension; LVEDV = left ventricular end-diastolic volume; LVESV = left ventricular end-systolic volume; LVFS = left ventricular fractional shortening; LVEF = left ventricular ejection fraction. All statistical analyses using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test.

a

indicates significance (at 0.05 level);

b

indicates significance (at 0.05 level);

c

indicates significance (at 0.05 level);

d

indicates significance (at 0.05 level).