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Lymph flowdecreases in colon tissuesafter blocking VEGFR-3 signaling in acute and chronic colitis. A. Anti-VEGFR-3-treated mice had a decreased lymph flow as compared to PBS-treated mice in acute colitis; B. In chronic colitis, anti-VEGFR-3-treated mice undergoing 3 cycles of 2% DSS treatment had more Evens Blue dyein the distal colons, especially from the second cycle, as compared to mice treated with PBS (t test, *P < 0.05).
