Skip to main content
. 2016 Feb 15;8(2):1155–1163.

Figure 3.

Figure 3

Administration with miR-223-3p agomir suppresses the expression of LIF in pregnant mice. MiR-223-3p agomir (miR-223-agomir) and negative control (miR-223-control) was administrated into the mouse uterine cavity on day 3 of pregnancy, respectively. A. The expression of miR-223-3p was increased approximately 2.5-fold in the miR-223-agomir treated group, compared with miR-223-control treated group (1.11±0.5 vs. 2.71±0.5, P<0.05) on day 4 of pregnancy. B. The expression of LIF mRNA was reduced approximately 50% in the miR-223-agomir treated group, compared with miR-223-control treated group (0.96±0.40 vs. 0.49±0.11, P=0.203) on day 4 of pregnancy. C. The expression of LIF protein in the endometrium of pregnant mice was detected by using immunohistochemistry. In miR-223-control treated group, the LIF protein was strongly expressed in endometrial epithelial cells and moderately expressed in stromal cells. In miR-223-agomir treated group, the LIF protein was weekly expressed in both endometrial epithelial cells and stromal cells.