Table 3.
Univariate analysis of factors associated with survival and progression of primary GBM patients
| Variable | Primary GBM | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| OS | PFS | |||||
|
|
|
|||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (≥55 vs. <55 y) | 1.773 | 1.169-2.690 | 0.005 | 1.691 | 1.120-2.555 | 0.009 |
| WDR1 (High vs. Low) | 2.085 | 1.314-3.308 | 0.001 | 1.844 | 1.173-2.897 | 0.005 |
| Chemotherapy (Yes vs. No) | 0.681 | 0.433-1.069 | 0.083 | 0.779 | 0.497-1.221 | 0.256 |
| IICP (Yes vs. no) | 0.855 | 0.567-1.289 | 0.439 | 0.849 | 0.564-1.278 | 0.414 |
| MTD (≥4 vs. <4 cm) | 1.142 | 0.754-1.731 | 0.517 | 1.401 | 0.928-2.116 | 0.094 |
| Cystic Degeneration (Yes vs. No) | 0.636 | 0.394-1.027 | 0.054 | 0.676 | 0.423-1.078 | 0.085 |
| Necrosis (Yes vs. No) | 1.137 | 0.651-1.988 | 0.641 | 1.323 | 0.770-2.276 | 0.292 |
| Radiotherapy (Yes vs. No) | 0.605 | 0.388-0.943 | 0.020 | 0.637 | 0.410-0.991 | 0.036 |
| Resection Degree | 0.034 | 0.094 | ||||
| Total vs. Partial | 0.223 | 0.068-0.725 | 0.013 | 0.291 | 0.090-0.939 | 0.039 |
| Subtotal vs. Partial | 0.196 | 0.056-0.678 | 0.010 | 0.256 | 0.075-0.878 | 0.030 |
| Seizure (Yes vs. No) | 1.334 | 0.689-1.582 | 0.376 | 1.391 | 0.718-2.694 | 0.308 |
| Gender (Female vs. Male) | 0.789 | 0.508-1.224 | 0.273 | 0.728 | 0.471-1.127 | 0.137 |
| Border on MRI (Clear vs. Unclear) | 1.049 | 0.611-1.801 | 0.859 | 1.042 | 0.607-1.788 | 0.877 |
Abbreviations: IICP, increased intracranial pressure; MTD, mean tumor diameter; HR, Hazard ratio; OS, overall survival; PFS, progression-free survival.