Table 4.
Multivariate analysis of factors associated with survival and progression of primary GBM patients
| Survival* | Median Survival (months, 95% CI) | HR | 95% CI | p | |
|---|---|---|---|---|---|
| OS | |||||
| Age (≥55 vs. <55 y) | 10 (8.351-11.649) | 15 (8.284-21.716) | 1.782 | 1.175-2.702 | 0.007 |
| WDR1 (High vs. Low) | 10 (8.545-11.455) | 15 (6.325-27.396) | 2.147 | 1.349-3.419 | 0.001 |
| Radiotherapy (Yes vs. No) | 12 (8.637-15.363) | 9 (6.858-11.142) | 0.616 | 0.395-0.960 | 0.032 |
| PFS | |||||
| Age (≥55 vs. <55 y) | 7 (5.084-8.916) | 12 (9.754-14.246) | 1.844 | 1.212-2.806 | 0.004 |
| WDR1 (High vs. Low) | 8 (6.741-9.259) | 10 (6.901-13.099) | 1.912 | 1.211-3.019 | 0.005 |
| Radiotherapy (Yes vs. No) | 10 (7.142-12.858) | 8 (5.322-10.678) | 0.528 | 0.327-0.852 | 0.009 |
Abbreviations: HR, hazard ratio; OS, overall survival; PFS, progression-free survival.
*
Variables were adopted for their prognostic significance by univariateanalysis (p≤0.2).