Table 3.
The contribution of 5-HTT LPR or VNTR genotype variance to the odds ratio for MDD, with or without controlling for psychosocial variables (PVs)
| OR (95% CI) | w/o PVs | p w/o PVs | OR’ (95% CI) | w PVs | p’ w PVs | ||
|---|---|---|---|---|---|---|---|
| Gender | F to M | 0.929 (0.623, 1.386) | 0.719 | 0.940 (0.533, 1.656) | 0.830 | ||
| Age | 1.010 (0.987, 1.033) | 0.402 | 1.014 (0.976, 1.054) | 0.477 | |||
| 5-HTT LPR Genotypes | ls to ll | 1.852 (0.813, 4.221) | 0.142 | 1.018 (0.314, 3.296) | 0.976 | ||
| ss to ll | 2.504* (1.116, 5.619) | 0.026 | 1.297 (0.410, 4.096) | 0.658 | |||
| EPQ | 1.029* (1.011, 1.048) | 0.001 | |||||
| LES | 1.008* (1.002, 1.015) | 0.012 | |||||
| SSRS | 0.922* (0.880, 0.966) | 0.001 | |||||
| TCSQ | Positive | 0.862* (0.827, 0.899) | 0.000 | ||||
| Negative | 1.104* (1.059, 1.151) | 0.000 | |||||
| Gender | F to M | 0.954 (0.642, 1.417) | 0.815 | 0.931 (0.530, 1.634) | 0.803 | ||
| Age | 1.014 (0.992, 1.037) | 0.205 | 1.017 (0.979, 1.056) | 0.393 | |||
| 5-HTT VNTR Genotypes | STin2.12/10 | 0.876 (0.503, 1.525) | 0.639 | 1.072 (0.511, 2.247) | 0.854 | ||
| STin2.10/10 | n.a. | n.a. | n.a. | n.a. | |||
| EPQ | 1.029* (1.012, 1.048) | 0.001 | |||||
| LES | 1.008* (1.002, 1.015) | 0.010 | |||||
| SSRS | 0.921* (0.879, 0.965) | 0.001 | |||||
| TCSQ | Positive | 0.861* (0.826, 0.897) | 0.000 | ||||
| Negative | 1.103* (1.058, 1.150) | 0.000 | |||||
OR: odds ratio of independent factors without PVs; OR’: odds ratio of independent factors including PVs; CI: confidence intervals;
*
p<0.05, considered statistically significant.