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. Author manuscript; available in PMC: 2016 May 25.
Published in final edited form as: Expert Opin Ther Targets. 2015 May 25;19(10):1307–1317. doi: 10.1517/14728222.2015.1043269

Figure 1. The shared import and export mechanisms of Cu and platinum drugs.

Figure 1

(A) hCtr1 transports Cu+1 by endocytosis, (B) The Cu chaperone Atox1 captures Cu by interacting with hCtr1. Cu is then transferred to ATP7A/ATP7B for eliminating by secretory vesicles. (C) The Cu chaperone CCS captures Cu by interacting with hCtr1. (D) hCtr1 may directly transport Cu into the cells.