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. Author manuscript; available in PMC: 2016 May 25.
Published in final edited form as: Expert Opin Ther Targets. 2015 May 25;19(10):1307–1317. doi: 10.1517/14728222.2015.1043269

Figure 2. Schematics of Cu homeostasis regulation.

Figure 2

(a) Cu depletion upregulates Sp1. (b) Upregulated Sp1 increases hCtr1 expression, (c) Increased hCtr1 enhances Cu transport. (d) Increased Cu suppresses hCtr1 expression. (e) Reduced Sp1 down-regulates hCtr1, resulting in reduced Cu (f).