Table 1.
Median and interquartile range (IQR) concentrations of interleukin (IL)-6 in supernatants from bronchial airway epithelial cell culture after exposure to lipopolysaccharide (L = lowest concentration = 1 µg/mL, I = intermediate concentration = 10 µg/mL and H = highest concentration = 100 µg/mL), house dust mite (L = lowest concentration = 5 µg/mL, I = intermediate concentration = 25 µg/mL and H = highest concentration = 50 µg/mL) and side stream cigarette smoke (concentrations the same as for house dust mite). Units are pg per mg protein content of the confluent cellular monolayer.
| Exposure | Lipopolysaccharide Median (IQR) n = 23 | House Dust Mite Median (IQR) n = 23 | Side Stream Cigarette Smoke Median (IQR) n = 18 |
|---|---|---|---|
| Negative control | 5.8 (1.1, 15.0) | 1.6 (0.1, 11.3) * | 4.1 (0.8, 18.3) |
| Exposure to L | 7.5 (1.5, 15.5) | 7.4 (0.5, 33.3) * | 7.4 (1.7, 22.1) ‡ |
| Exposure to I | 5.4 (0.9, 16.7) | 13.5 (1.1, 22.8) * | 5.1 (1.0, 16.0) ‡ |
| Exposure to H | 4.2 (0.6, 11.4) | 9.8 (1.9, 23.9) * | 4.9 (1.1, 10.9) ‡ |
| Exposure to TNFa and IL-1B | 64.1 (8.2, 132.8) | 63.4 (8.2, 136.9) | 57.4 (5.9, 79.9) |
* p < 0.001 from Friedman’s test when three exposures groups plus negative control included; ‡ p = 0.023 from Friedman’s test when only the exposure groups were included.