Table 5.
Median and interquartile range (IQR) concentrations of intracellular adhesion molecule in supernatants from bronchial airway epithelial cell culture after exposure to lipopolysaccharide (L = lowest concentration = 1 µg/mL, I = intermediate concentration = 10 µg/mL and highest concentration = 100 µg/mL), house dust mite (L = lowest concentration = 5 µg/mL, I = intermediate concentration = 25 µg/mL and H = highest concentration = 50 µg/mL) and side stream cigarette smoke (concentrations the same as for house dust mite).
| Exposure | Lipopolysaccharide Median (IQR) n = 24 | House Dust Mite Median (IQR) n = 23 | Side Stream Cigarette Smoke Median (IQR) n = 18 |
|---|---|---|---|
| Negative control | 0.58 (0.22, 1.23) | 0.34 (0.00, 0.75) * | 0.55 (0.21, 1.42) † |
| Exposure to L | 0.53 (0.28, 1.12) | 0.71 (0.44, 1.46) * | 0.89 (0.27, 1.76) † |
| Exposure to I | 0.30 (0.13, 1.11) | 1.00 (0.27, 1.53) * | 0.42 (0.07, 0.80) † |
| Exposure to H | 0.43 (0.21, 1.07) | 0.78 (0.39, 1.60) * | 0.31 (0.11, 1.70) † |
| Exposure to TNFa and IL-1B | 1.42 (0.46, 3.44) | 1.58 (0.43, 3.73) | 1.43 (0.60, 4.25) |
Units are pg per mg protein content of the confluent cellular monolayer. * p = 0.001 from Friedman’s test when three exposure groups and negative control were included; † p = 0.031 for Friedman’s test across three exposure groups and p = 0.045 for Friedman’s test across three exposure groups plus negative control.