Representative immunoprofile of tumors evaluated in this study included in the morphologic differential diagnosis of chordoid meningioma. Extraskeletal myxoid chondrosarcoma: (A) D2-40 negative, (B) S100 positive, (C) pankeratin positive (patchy, weak), and (D) EMA negative. Chordoma: (E) D2-40 negative, (F) S100 positive, (G) pankeratin positive, and (H) EMA positive. Low-grade chondrosarcoma, enchondroma, and skeletal myxoid chondrosarcoma: (I/M/Q) D2-40 positive, (J/N/R) S100 positive, (K/O/S) pankeratin negative, and (L/P/T) EMA negative. Chordoid glioma: (U) D2-40 positive, (V) S100 positive, (W) pankeratin positive, and (X) EMA positive. EMA indicates epithelial membrane antigen.