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. 2016 Apr 27;13:92. doi: 10.1186/s12974-016-0557-z

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© Lee et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Loss of function of TRPA1 channels improves nest building and spatial learning and memory in APP/PS1 Tg mice. (a) PCR genotyping of representative WT, TRPA1^−/−, APP/PS1 Tg and APP/PS1 Tg/TRPA1^−/− mice. PS1 = 608 bp, APP = 377 bp, TRPA1^+/+ = 317 bp and TRPA1^−/− = 184 bp. (b, c) Representative examples and the score for nest building for 8-month-old WT, TRPA1^−/−, APP/PS1 Tg and APP/PS1 Tg/TRPA1^−/− mice. (d-g) Schematic diagram of Y-maze experimental design and ratio of first entry, number of entries and distance moved in the novel arm. (h) Morris water maze (MWM) test of learning patterns verified on days 1 to 4. (i, j) At day 5 after training, the number of times crossing the hind platform and retention times in the all quadrants. (k) The latency of arrival to the visual platform. Data are mean ± SEM from 8 mice in each group. *, P < 0.05 vs. WT mice or day 1 (h panel), #, P < 0.05 vs. APP/PS1 Tg mice, $ P < 0.05 vs. WT mice (h panel)