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. 2016 Apr 27;13:92. doi: 10.1186/s12974-016-0557-z

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© Lee et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Ablation of TRPA1 channel function decreases Aβ deposition in brain lesions of APP/PS1 Tg mice. (a) Immunostaining of specimens of hippocampus and cortex from 8-month-old WT, TRPA1^−/−, APP/PS1 Tg and APP/PS1 Tg/TRPA1^−/− mice with anti-Aβ antibody, then FITC-conjugated secondary antibody. (b, c) Western blot analysis of protein levels of oligomer (oligo) or monomer (mono) Aβ, βCTF, ABCA1, LRP-1, apoE and α-tubulin in brain specimens. Bar = 100 μm. Data are mean ± SEM from 8 mice in each group. *, P < 0.05 vs. WT mice. #, P < 0.05 vs. APP/PS1 Tg mice