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. 2016 Apr 27;4:43. doi: 10.1186/s40478-016-0313-8

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© Pickles et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Misfolded SOD1-specific antibodies have distinct labeling patterns in SOD1^G93A rat spinal cords. Immunohistochemistry for misfolded SOD1 in SOD1^G93A lumbar spinal cords. a Lumbar sections of a symptomatic SOD1^G93A rat were stained with misfolded SOD1 specific antibody A5C3 (green) and co-labeled with ChAT (blue). Additional representative images of B8H10, C4F6, D3H5, DSE2-3H1 and AMF7-63 are also shown. b The AMF7-63 antibody detects fibrils in pre-symptomatic, 14 and 15 week SOD1^G93A rat spinal cords. c Symptomatic SOD1^G93A rat spinal cord was labeled with AMF7-63 (green) and SMI32 (red), SMI31 (red), or MAP2 (red). d Lumbar sections labeled with misfolded SOD1 antibodies AMF7-63 (blue), B8H10 (green), and co-labeled with ChAT (red). Two to three animals of each genotype were analyzed. Scale bar = 100 μm for (a, b and d) and 25 μm for (c)