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. 2016 Apr 27;17:186. doi: 10.1186/s12859-016-1054-1

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© Zhang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Illustration of DPPN construction. a a static PPI network based on high-throughput PPI data. b the gene expression value of protein v1. c active time attributes and active probability of protein vertices calculated based on gene expression data. d a DPPN constructed based on a and c