Table 2.
Demographic data, exposure, and HPV-related disease history among participants segregated by oral swab statusf
| Characteristic | Patients (N = 198) | Partners (N = 198) | ||||
|---|---|---|---|---|---|---|
| Swab positive (N = 28) | Swab negative (N = 170) | p-Value | Swab positive (N = 30) | Swab negative (N = 168) | p-value | |
| Age, years | ||||||
| < 55 | 12 (42.9 %) | 76 (44.7 %) | .86 | 15 (50 %) | 93 (56 %) | .54 |
| ≥ 55 | 16 (57.1 %) | 94 (55.3 %) | 15 (50 %) | 73 (44 %) | ||
| Sex | ||||||
| Female | 5 (17.9 %) | 32 (18.8 %) | 1.0 | 26 (86.7 %) | 135 (80.4 %) | .61 |
| Male | 23 (82.1 %) | 138 (81.2 %) | 4 (13.3 %) | 33 (19.6 %) | ||
| Race | ||||||
| White | 22 (78.6 %) | 156 (91.8 %) | .032 | 23 (76.7 %) | 134 (79.8 %) | .70 |
| Other | 6 (21.4 %) | 14 (8.2 %) | 7 (23.3 %) | 34 (20.2 %) | ||
| Smoking statusa | ||||||
| Former/never | 14 (70.0 %) | 80 (71.4 %) | .90 | 13 (61.9 %) | 61 (67.8 %) | .61 |
| Current | 6 (30 %) | 32 (28.6 %) | 8 (38.1 %) | 29 (32.2 %) | ||
| Prior alcohol useb | ||||||
| None | 3 (11.1 %) | 15 (8.9 %) | .72 | 6 (20 %) | 34 (21.1 %) | .89 |
| Yes | 24 (88.9 %) | 154 (91.1 %) | 24 (80 %) | 127 (78.9 %) | ||
| Prior HPV-related disease | ||||||
| None | 28 (100.0 %) | 157 (93.5 %) | .37 | 23 (76.7 %) | 133 (80.1 %) | .67 |
| Yes | 0 (0.0 %) | 11 (6.5 %) | 7 (23.3 %) | 33 (19.9 %) | ||
| Prior benign HPV-related diseasec | ||||||
| None | 28 (100.0 %) | 165 (97.1 %) | 1.0 | 30 (100 %) | 161 (95.8 %) | .60 |
| Yes | 0 (0.0 %) | 5 (2.9 %) | 0 (0 %) | 7 (4.2 %) | ||
| Prior HPV-related malignancyd | ||||||
| None | 27 (96.4 %) | 165 (97.1 %) | 1.0 | 29 (96.7 %) | 163 (97 %) | 1.0 |
| Yes | 1 (3.6 %) | 5 (2.9 %) | 1 (3.3 %) | 5 (3 %) | ||
| HPV status of oropharyngeal tumore | ||||||
| Negative | 2 (11.8 %) | 14 (11 %) | 1.0 | 2 (10.5 %) | 14 (11.2 %) | 1.0 |
| Positive | 15 (88.2 %) | 113 (89 %) | 17 (89.5 %) | 111 (88.8 %) | ||
| Oral mouth swab status of matched pair | ||||||
| HPV Negative | 9 (32.1 %) | 159 (93.5 %) | <.001 | 11 (36.7 %) | 159 (94.6 %) | <.001 |
| HPV Positive | 19 (67.9 %) | 11 (6.5 %) | 19 (63.3 %) | 9 (5.4 %) | ||
a8 swab positive and 58 swab negative patients had missing data on smoking; 1 swab positive and 1 swab negative patient had missing data on prior alcohol use
b9 swab positive and 78 swab negative partners had missing data on smoking; 7 swab negative partners had missing data on prior alcohol use
cbenign HPV-related disease defined as CIN I-III, dysplasia
dCervical cancer, anal cancer, prior HNSCC cancer
eBy p16 IHC (N = 121) or HPV ISH (N = 104); data were unavailable for 54 patients
fPercentages are calculated as a column percentage