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. 2015 Jul 29;51(70):13470–13473. doi: 10.1039/c5cc05469a

Scheme 1. Routes to bicyclic peptide structures involving cysteine modification. (A) A two-step modification in which cysteine is first converted to dehydroalanine followed by cyclisation with a trithiol, ultimately generating 8 stereoisomers of the peptide produced in Route B. (B) Alkylation of 3 cysteine residues with a central mesitylene core.

Scheme 1