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. Author manuscript; available in PMC: 2017 Feb 5.
Published in final edited form as: J Proteome Res. 2016 Jan 12;15(2):563–571. doi: 10.1021/acs.jproteome.5b00957

Figure 2.

Figure 2

Liver metabolism shifts to a more catabolic state in conventionally-raised mice treated with increasing doses of tempol. (A) Conventionally-raised mouse liver metabolic profiles of control group (black circles) and 1 mg/kg (red squares), 10 mg/kg (blue squares), and 50 mg/kg (purple asterisks) tempol groups determined by 1H NMR. O-PLS-DA scores (left) and coefficient-coded loadings plots (right) for the models obtained from the 1H NMR liver spectra (n=5 mice per group). (B) Comparison of germ-free mice liver metabolites between control group (back circles) and 50 mg/kg tempol group (red squares) determined by 1H NMR (n=5 mice per group).