Table 1.
Baseline Demographic and Clinicopathologic Characteristics Stratified by Time from Diagnosis to Resection < 3 months vs ≥ 3 months
| Variable | Study cohort | Time from diagnosis to surgery < 3 mo |
Time from diagnosis to surgery ≥ 3 mo |
p Value |
|---|---|---|---|---|
| n | 513 | 394 (76.8) | 119 (23.20 | |
| Sex | 0.52 | |||
| Female | 194(37.8) | 152(38.6) | 42(35.3) | |
| Male | 319(62.2) | 242(61.4) | 77(64.7) | |
| Age, y | 64.1(11.5) | 63.6(11.4) | 65.7(11.7) | 0.08 |
| BMI, kg/m2 | 28.3(5.5) | 28.2(5.4) | 28.3(5.6) | 0.95 |
| Type of initial referral | 0.55 | |||
| Medical | 61(11.9) | 45(11.4) | 16(13.4) | |
| Surgical | 452(88.1) | 349(88.6) | 103(86.6) | |
| Year of surgery | 0.06 | |||
| 2000-05 | 259(50.5) | 208(52.8) | 51(42.9) | |
| 2006-10 | 254(49.5) | 186(47.2) | 68(57.1) | |
| Preoperative PVE | 18(3.5) | 6(1.5) | 12(10.1) | <0.0001 |
| Lymph node + primary | 227(44.2) | 174(44.2) | 53(44.5) | 0.68 |
| Preoperative CEA, ng/mL | 0.72 | |||
| CEA ≤ 200 | 424(82.7) | 336(85.3) | 88(73.9) | |
| CEA >200 | 12(2.3) | 9(2.3) | 3(2.5) | |
| Diameter of largest metastasis, cm | 0.94 | |||
| ≤5 | 374(72.9) | 287(72.8) | 87(73.1) | |
| > 5 | 135(26.3) | 104(26.4) | 31(26.1) | |
| No. of metastases | 0.07 | |||
| 1 | 316(61.6) | 252(64.0) | 64(53.8) | |
| >1 | 194(37.8) | 141(35.8) | 53(44.5) | |
| Disease-free interval, mo | 26.7(21.5) | 0.56 | ||
| <12 | 91(17.7) | 68(17.3) | 23(19.3) | |
| ≥ 12 | 414(80.7) | 321(81.5) | 93(78.2) | |
| Clinical Risk Score | 0.82 | |||
| 0 | 88(17.2) | 71(18.0) | 17(14.3) | |
| 1 | 232(45.2) | 179(45.4) | 53(44.5) | |
| 2 | 136(26.5) | 102(25.9) | 34(28.6) | |
| 3 | 47(9.2) | 34(8.6) | 13(10.9) | |
| 4 | 5(1.0) | 4(1.0) | 1(0.8) | |
| 5 | - | - | - | |
| Low risk (0-2) | 456(88.9) | 352(89.3) | 104(87.4) | 0.51 |
| High risk (3-5) | 52(10.1) | 38(9.6) | 14(11.8) | |
| Time from diagnosis to referral, mo |
0.65 +/− 1.43 | 0.21+/−0.43 | 2.13+/−2.30 | <0.0001 |
| Time from referral to resection, mo |
0.68 +/− 1.04 | 0.41+/−0.60 | 1.56+/−1.56 | <0.0001 |
| Time from diagnosis to resection, mo |
1.92 +/− 2.5 | 0.98+/−0.70 | 5.06+/−3.46 | <0.0001 |
Percentages for individual variables are tabulated based on total number of patients in each group (n= 394, diagnosis to resection <3 months and n=119, diagnosis to resection ≥ 3 months). Categorical data are presented as frequency (%) and continuous data mean +/− standard deviation. p<0.05 was considered significant.
PVE, portal vein embolization; CEA, carcinoembryonic antigen.