Table 2.
Operative Characteristics and Postoperative Outcomes of Patients with Resectable Colorectal Liver Metastases Stratified by Time from Diagnosis to Resection < 3 months vs ≥ 3 months
| Variable | Study cohort |
Time from
diagnosis to resection < 3 mo |
Time from
diagnosis to resection ≥ 3 mo |
p Value |
|---|---|---|---|---|
| n (%) | 513 | 394(76.8) | 119(23.2) | |
| Operative procedure, n (%) |
0.05 | |||
| Wedge | 26(5.1) | 22(5.6) | 4(3.4) | |
| Right lobectomy | 144(28.1) | 107(27.2) | 37(31.1) | |
| Left lobectomy | 54(10.5) | 44(11.2) | 10(8.4) | |
| Right trisegmentectomy |
43(8.4) | 25(6.3) | 18(15.1) | |
| Left trisegmentectomy |
16(3.1) | 12(3.0) | 4(3.4) | |
| Central hepatectomy |
11(2.1) | 10(2.5) | 1(0.8) | |
| Anatomic segmentectomy or sectorectomy |
219(42.7) | 174(44.2) | 45(37.8) | |
| Procedure time, 30 minute blocks (%) |
7.3(2.6) | 7.2(2.5) | 7.6(2.7) | 0.17 |
| EBL, per 100 mL, (%) | 5.6(6.6) | 5.6(7.2) | 5.6(4.4) | 0.97 |
| LOS, d, mean±SD | 7.0+/− | 7.8+/−4.9 | 8.8+/−9.2 | 0.10 |
| 30-d Complication, n (%) |
146(28.5) | 112(28.4) | 34(28.6) | 0.98 |
| Major complication, n (%) |
63(12.3) | 46(11.7) | 17(14.3) | 0.45 |
| 30-d Mortality , n (%) | 1(0.2) | 1(0.3) | 0(0.0) | 0.59 |
| 60-d Mortality, n (%) | 6(1.2) | 5(1.2) | 1(0.8) | 0.72 |
| Margin status , n (%) | 0.68 | |||
| Positive | 53(10.3) | 42(10.7) | 11(9.2) | |
| Negative | 459(89.5) | 352(89.3) | 107(89.9) | |
| Adjuvant chemotherapy, n (%) |
0.004 | |||
| Yes | 318(62) | 260(66.0) | 58(48.7) | |
| No | 139(27) | 97(24.6) | 42(35.3) | |
| Disease recurrence, n (%) |
0.25 | |||
| Yes | 243(47.4) | 192(48.7) | 51(42.9) | |
| No | 269(52.4) | 201(51.0) | 68(57.1) | |
| Time to recurrence, mo (minimum to maximum) |
13.0(1-80) | 13(1-80) | 13(3-73) | 0.72 |
| Site of first recurrence, n (%) |
0.96 | |||
| Lung | 103(20.1) | 79(20.1) | 24(20.2) | |
| Nodal | 17(3.3) | 14(3.6) | 3(2.5) | |
| Liver | 77(15.0) | 60(15.2) | 17(14.3) | |
| Local/pelvic | 12(2.3) | 10(2.5) | 2(1.7) | |
| Peritoneal | 15(2.9) | 13(3.3) | 2(1.7) | |
| Anastomotic | 3(0.6) | 2(0.5) | 1(0.8) | |
| Adrenal | 1(0.2) | 1(0.3) | 0(0) | |
| Other | 14(2.7) | 12(3.0) | 2(1.7) | |
| Status at last follow up, n (%) |
0.86 | |||
| NED | 291(56.7) | 221(56.1) | 70(58.8) | |
| AWD | 198(38.6) | 152(38.6) | 43(36.1) | |
| DWD | 24(4.7) | 18(4.6) | 6(5.0) | |
| Follow-up time, mo (minimum to maximum) |
37.0(0-163) | 40(0-163) | 32(0-146) | 0.02 |
Percentages for individual variables are tabulated based on total number of patients in each group (n= 394, Dx-Rx <3 months and n=119, Dx-Rx ≥ 3 months). Categorical data are presented as frequency (%), continuous data as mean +/− standard deviation and follow-up time/time to recurrence are presented as median (min-max). p<0.05 was considered significant.
EBL, estimated blood loss; LOS, length of stay; NED, no evidence of disease; AWD, alive with disease; DWD, dead with disease.