Table 3.

Univariate and Multivariable Recurrence-Free Survival Analysis for Patients with Low Volume, Metachronous, Colorectal Liver Metastases

Variable	Univariate HR	Univariate 95% CI	p Value	Multivariable HR	Multivariable 95% CI	p Value
Age, y	1.02	(1.01-1.03)	0.004	1.01	1.00-1.03	0.01
Hospital			0.02			0.03
1	1.0 (ref)	-		1.0 (ref)	-
2	1.22	(0.86-1.71)		1.09	0.76-1.57
3	1.49	(1.15-1.93)		1.52	1.15-2.03
4	0.95	(0.54-1.67)		0.83	0.42-1.62
EBL, per 100 mL	1.02	(1.00-1.03)	0.02	1.01	1.00-1.02	0.13
Pringle time, min	1.02	(1.01-1.03)	0.004	-	-	-
No. of metastases			0.06			0.31
1	1.0 (ref)	-		1.0 (ref)	-
>1	1.24	(0.99-1.55)		1.14	0.89-1.46
Diameter of largest metastases, cm			0.02			0.01
≤ 5	1.0 (ref)	-		1.0 (ref)	-
>5	1.34	(1.05-1.70)		1.40	1.08-1.82
Clinical risk score			<0.0001
Low risk(0-  2)	1.0 (ref)	-		-	-	-
High risk(3-  5)	1.86	(1.35-2.57)
Positive resection margin	1.43	(1.03-1.99)	0.03	1.38	0.97-1.97	0.07
30-d Complication	1.23	(0.97-1.56)	0.09	0.98	0.75-1.28	0.88
Adjuvant chemotherapy	0.78	(0.60-1.00)	0.05	-	-	-

53 (11%) patients and 262 (51%) of patients were missing data pertaining to adjuvant chemotherapy use and Pringle time, respectively, as such these were not included in the final multivariable model. Clinical risk score was correlated with tumor size (Spearman r=0.17, p<0.0001) and was excluded from the final multivariable model.

HR, hazard ratio; 95% CI, 95% confidence interval; (ref), reference category; EBL, estimated blood loss.