Table 4.
Univariate and Multivariable Overall Survival Analysis for Patients with Low Volume, Metachronous, Colorectal Liver Metastases
| Variable | Univariate HR |
Univariate 95% CI |
P-value | Multivariabl e HR |
Multivariabl e 95% CI |
p Value |
|---|---|---|---|---|---|---|
| Age | 1.02 | (1.01-1.03) | 0.001 | 1.02 | 1.00-1.03 | 0.005 |
| BMI | 0.97 | (0.94-0.99) | 0.02 | 0.97 | 0.94-1.00 | 0.04 |
| Hospital | <0.0001 | <0.0001 | ||||
| 1 | 1.0 (ref) | - | 1.0 (ref) | - | ||
| 2 | 1.07 | (0.69-1.66) | 0.56 | 0.33-0.95 | ||
| 3 | 1.92 | (1.43-2.57) | 1.8 | 1.28-2.53 | ||
| 4 | 0.95 | (0.48-1.87) | 0.79 | 0.34-1.81 | ||
| Primary procedure | 0.02 | 0.12 | ||||
| Wedge | 1.0 (ref) | - | 1.0 (ref) | - | ||
| Right lobectomy | 0.80 | (0.45-1.42) | 0.77 | 0.37-1.58 | ||
| Left lobectomy | 0.65 | (0.33-1.28) | 0.56 | 0.24-1.29 | ||
| Right trisegmentectomy |
0.93 | (0.48-1.82) | 0.98 | 0.43-2.23 | ||
| Left trisegmentectomy |
1.01 | (0.45-2.28) | 0.86 | 0.33-2.26 | ||
| Central hepatectomy |
2.12 | (0.89-5.07) | 2.21 | 0.79-6.20 | ||
| Anatomic segmentectomy |
0.63 | (0.36-1.11) | 0.71 | 0.36-1.39 | ||
| EBL, per 100 mL | 1.02 | (1.01-1.04) | 0.006 | 1.02 | 1.0-1.04 | 0.05 |
| No. of metastases | 0.06 | 0.64 | ||||
| 1 | 1.0 (ref) | - | 1.0 (ref) | - | ||
| >1 | 1.29 | (0.99-1.67) | 1.08 | 0.79-1.47 | ||
| Diameter of largest metastases, cm |
0.003 | 0.02 | ||||
| ≤5 | 1.0 (ref) | - | 1.0 (ref) | - | ||
| >5 | 1.51 | (1.15-1.99) | 1.45 | 1.07-2.00 | ||
| Clinical risk score | 0.001 | |||||
| Low risk (0-2) | 1 (ref) | - | - | - | - | |
| High risk (3-5) | 1.84 | (1.28-2.65) | - | - | - | |
| Time from Dx-Rf | 1.08 | (1.01-1.17) | 0.03 | - | - | - |
| Time from Dx-Rx | 1.06 | (1.01-1.12) | 0.01 | 1.12 | 1.06-1.18 | <0.0001 |
| 30-d Complication | 1.29 | (0.97-1.70) | 0.08 | 0.81 | 0.54-1.22 | 0.31 |
| Major complication | 1.47 | (1.03-2.10) | 0.04 | 1.15 | 0.75-1.75 | 0.53 |
| Positive resection margin |
1.44 | (0.98-2.10) | 0.06 | 1.07 | 0.69-1.65 | 0.77 |
| Adjuvant chemotherapy |
0.58 | (0.43-0.78) | <0.0001 | - | - | - |
| Recurrence | 2.69 | (2.03-3.57) | <0.0001 | 2.68 | 1.95-3.67 | <0.0001 |
53 (11%) patients were missing data pertaining to adjuvant chemotherapy use and were not included in the final multivariable model. Clinical risk score correlated with tumor size (Spearman r=0.17, p<0.0001), and time from Dx-Rf correlated with time from Dx-Rx (Spearman r=0.6) and were excluded from multivariable model.
HR, hazard ratio; 95% CI, 95% confidence interval; (ref), reference category; BMI, basal metabolic index; EBL, estimated blood loss; Dx-Rf, diagnosis to referral; Dx-Rx, diagnosis to resection.