Table 1.

Summary of differences in adipokines and cytokines between IIH and controls

Cytokine/adipokine	CSF	References	Serum	References
Leptin	↑	25	↑	26
	–	28
		27
Adiponectin	↓	25	↓	25
Ghrelin			–	81
CCL7			↑	27
CCL8			↑	27
CCL2/MCP1	↑	27
	−	25
IFN-γ	↑	82	↑	43
		43
IL-1α			↑	27
IL-1β	−	25	↑	82
		82
IL-2	↑	25
IL-4	↑	82	↑	43
		43
	–	25
IL-6	↑	83
IL-10	↑	82	↑	43
		43
	–	83
IL-12	↑	43	↑	43
IL-17	↑	82	↑	43
		43
TNF-α	↑	25	–	43

Notes: – denotes no significant difference, ↑ denotes raise in IIH, and ↓ denotes decrease in IIH. There was no significant difference between IIH and controls for IL-8, HGF, NGF, OPN, PA1, and TGF-β in either the CSF or serum.²⁵,⁸²

Abbreviations: CCL, chemokine ligand; CSF, cerebrospinal fluid; HGF, hepatocyte growth factor; IFN, interferon; IIH, Idiopathic intracranial hypertension; IL, interleukin; MCP1, monocyte chemotactic protein 1; NGF, nerve growth factor; TGF-β, transforming growth factor; TNF-α, tumor necrosis factor-α; OPN, Osteopontin: PAI, Plasminogen activator inhibitor 1.