Table 3.

Incidence or mortality rate (per 1,000 person-years) of heart failure and cardiac death among soft tissue sarcoma (STS) patients in Denmark (national cohort), 2000–2009

Characteristics	Heart failure					Cardiac death
	Total N	Number of events	%	Person- years	Incidence rate (95% confidence interval)	Number of events	%	Person- years	Mortality rate (95% confidence interval)
Total	1,187	40	3.4	5,449.2	7.3 (5.4–10.0)	15	1.3	5,510.6	2.7 (1.6–4.5)
Age, years
<40	226	1	0.4	1,217.0	0.8 (0.1–5.8)	0	0.0	1,219.2	–
40–59	379	6	1.6	2,095.9	2.9 (1.3–6.4)	0	0.0	2,104.4	–
60–79	461	21	4.6	1,795.2	11.7 (7.6–17.9)	9	2.0	1,835.4	4.9 (2.6–9.4)
≥80	121	12	9.9	341.1	35.2 (20.0–61.9)	6	5.0	351.6	17.1 (7.7–38.0)
Sex
Female	535	20	3.7	2,410.9	8.3 (5.4–12.9)	5	0.9	2,445.6	2.0 (0.9–4.9)
Male	652	20	3.1	3,038.4	6.6 (4.2–10.2)	10	1.5	3,065.0	3.3 (1.8–6.1)
STS subtype
Liposarcoma	392	14	3.6	2,112.5	6.6 (3.9–11.2)	3	0.8	2,149.2	1.4 (0.5–4.3)
Leiomyosarcoma	381	13	3.4	1,661.6	7.8 (4.5–13.5)	8	2.1	1,675.3	4.8 (2.4–9.5)
Fibrosarcoma	92	3	3.3	390.1	7.7 (2.5–23.8)	2	2.2	391.9	5.1 (1.3–20.4)
Synovial	84	2	2.4	322.5	6.2 (1.6–24.8)	0	0	322.6	–
Hemangiosarcoma	78	5	6.4	235.7	21.2 (8.8–51.0)	1	1.3	240.5	4.2 (0.6–29.5)
Rhabdomyosarcoma	74	0	0	298.3	–	0	0	298.3	–
Kaposi’s	66	3	4.5	363.4	8.3 (2.7–25.6)	1	1.5	367.7	2.7 (0.4–19.3)
Neurofibrosarcoma	18	0	0	58.7	–	0	0	58.7	–
Lymphangiosarcoma	2	0	0	6.4	–	0	0	6.4	–
Event timing after
STS diagnosis, years	1,187
<1		13	1.1	1,076.1	12.1 (7.0–20.8)	6	0.5	1,079.4	5.6 (2.5–12.4)
<2		20	1.7	2,001.5	10.0 (6.4–15.5)	9	0.8	2,012.8	4.5 (2.3–8.6)
<5		33	2.8	3,995.8	8.3 (5.9–11.6)	13	1.1	4,034.6	3.2 (1.9–5.5)

Abbreviations: –, not available; STS, soft tissue sarcoma.