Fig. 4. The proline triplet of ValS is required for viability of E. coli.
(A) Scheme for ValS complementation system. (B-G) Growth curves (OD600nm) of E. coli strains (B) BW25113, JL001, JL001 + pUlp1, or (C-G) JL001 bearing additional plasmids expressing pUlp1, and/or (C) wildtype ValS (pValS-PPP) or ValS mutants (D) pValS-GPP, (E) pValS-PGP, (F) pValS-PPG or (G) pValS-GGG. (H) Comparison of growth (after 90 min) of JL001 bearing plasmids expressing pUlp1 and pValS/XPP mutants normalized by subtraction of background growth in the presence of pUlp1 alone.