Table 1.
Proteins differentially expressed in the ELC transgenic mouse models of physiological (Δ43) versus pathological (A57G) cardiac hypertrophy
| Protein | Accession number | Molecular weight (kDa) | Mann–Whitney test (Bonferroni corrected) P value |
Δ43 versus A57G* (FC) |
|---|---|---|---|---|
| Elongation factor 2 | EF2_MOUSE | 95 | <0.0001 | −1.16 |
| Complement C3 | CO3_MOUSE | 186 | <0.0001 | −1.15 |
| Aldehyde dehydrogenase, mitochondrial | ALDH2_MOUSE | 57 | <0.0001 | −1.46 |
| Heat shock protein HSP 90-beta | HS90B_MOUSE | 83 | <0.0001 | −1.14 |
| Leucine-rich PPR motif-containing protein, mitochondrial | LPPRC_MOUSE | 157 | <0.0001 | −1.17 |
| NAD(P) transhydrogenase, mitochondrial | NNTM_MOUSE | 114 | <0.0001 | −1.46 |
| Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | AL4A1_MOUSE | 62 | <0.0001 | −1.25 |
| Stress-induced-phosphoprotein 1 | STIP1_MOUSE | 63 | <0.0001 | −1.15 |
| Cluster of Troponin T, cardiac muscle | K3W4R6_MOUSE | 35 | 0.00018 | 1.14 |
| Mitochondrial 2-oxoglutarate/malate carrier protein | M2OM_MOUSE | 34 | 0.0017 | −1.29 |
| Alpha-1B-glycoprotein | A1BG_MOUSE | 57 | 0.0018 | 1.39 |
| Elongation factor 1-gamma | EF1G_MOUSE | 50 | 0.0025 | −1.14 |
| Cluster of Myosin-6 | MYH6_MOUSE | 224 | 0.0039 | 1.11 |
| Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial | SUCB2_MOUSE | 47 | 0.0068 | −1.14 |
| Cluster of Inorganic pyrophosphatase 2, mitochondrial | D3Z636_MOUSE | 38 | 0.0069 | −1.25 |
| Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial | CHCH3_MOUSE | 26 | 0.0083 | 1.18 |
| Cluster of Myosin regulatory light chain 2, ventricular/cardiac muscle isoform | MLRV_MOUSE | 19 | 0.011 | 1.08 |
| Histidine rich calcium binding protein, isoform CRA_a | G5E8J6_MOUSE | 85 | 0.017 | −1.10 |
| Clathrin heavy chain 1 | CLH1_MOUSE | 192 | 0.017 | 1.25 |
| Sarcalumenin | SRCA_MOUSE | 99 | 0.02 | −1.12 |
| Cytochrome c oxidase subunit 5B, mitochondrial | COX5B_MOUSE | 14 | 0.02 | 1.12 |
| Serpin H1 | SERPH_MOUSE | 47 | 0.021 | −1.15 |
| Calcium-binding mitochondrial carrier protein Aralar1 | CMC1_MOUSE | 75 | 0.024 | −1.12 |
| Short-chain specific acyl-CoA dehydrogenase, mitochondrial | ACADS_MOUSE | 45 | 0.031 | −1.15 |
| Heterogeneous nuclear ribonucleoprotein U | G3XA10_MOUSE | 87 | 0.038 | −1.19 |
| Cluster of Long-chain-fatty-acid–CoA ligase 1 | ACSL1_MOUSE | 78 | 0.039 | −1.05 |
| Citrate lyase subunit beta-like protein, mitochondrial | CLYBL_MOUSE | 38 | 0.042 | −1.12 |
| Cytochrome b-c1 complex subunit 7 | Q9CQB4_MOUSE | 14 | 0.046 | 1.15 |
| Isovaleryl-CoA dehydrogenase, mitochondrial | IVD_MOUSE | 46 | 0.048 | −1.11 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | E9QPX3_MOUSE | 20 | 0.048 | 1.19 |
Negative fold change (FC) values indicate proteins that were significantly downregulated in Δ43 versus A57G hearts, while positive values indicate proteins that were significantly upregulated in Δ43 versus A57G hearts with significance (*) defined as P < 0.05