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. Author manuscript; available in PMC: 2017 Feb 19.
Published in final edited form as: ACS Chem Biol. 2015 Dec 14;11(2):415–424. doi: 10.1021/acschembio.5b00731

Figure 2.

Figure 2

Thiostrepton A and the analogues generated by site-directed mutagenesis of TsrA Ala2. a) Wild-type TsrA sequence with Ala2 of the core peptide highlighted in red. b) Structures of the thiostrepton Ala2 analogues. The observed analogues possessing no posttranslational modification(s) of the variant residue are presented in the top panel and in red, while the ones bearing a posttranslational modification of the variant residue are presented in the middle panel and in blue. The variants that led to a contracted quinaldic acid loop are shown in the bottom panel and in black.