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. Author manuscript; available in PMC: 2017 Feb 19.

Published in final edited form as: ACS Chem Biol. 2015 Dec 14;11(2):415–424. doi: 10.1021/acschembio.5b00731

Table 1.

MIC values of thiostrepton Ala2 analogues

Compound	MIC^a (μg mL⁻¹)
Compound	MRSA^b	VRE^c	Bacillus ^d
Thiostrepton A	0.012	0.012	0.025
Ala2Dha	0.010	0.008	0.042
Ala2Dhb	0.11	0.11	0.11
Ala2Gly	0.023	0.019	0.19
Ala2Ile-ΔIle1	>5.0	>5.0	>5.0
Ala2Met	0.014	0.007	0.086
Ala2Phe	0.022	0.011	0.087
Ala2Tyr	0.22	0.11	0.27
Ala2Val-ΔIle1	>5.0	>5.0	>5.0
Vancomycin	0.39	ND^e	ND
Chloramphenicol	ND	3.9	0.98

^a

Minimum inhibitory concentration.

^b

Staphylococcus aureus ATCC 10537.

^c

Enterococcus faecium ATCC 12952.

^d

Bacillus sp. ATCC 27859.

^e

Not determined.