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. Author manuscript; available in PMC: 2016 Sep 16.
Published in final edited form as: Nature. 2016 Mar 16;531(7595):508–512. doi: 10.1038/nature17172

Extended Data Figure 7. Behavioral rescue and spine restoration by optical LTP is protein-synthesis dependent.

Extended Data Figure 7

a, Modified behavioral schedule for long-term rescue of memory recall in AD mice in the presence of saline or anisomycin (left). Memory recall 2 days after LTP induction followed by drug administration showed less freezing of AD mice treated with anisomycin (AD + 100 Hz + Aniso) compared to saline treated AD mice (AD + 100 Hz + Saline, n = 9 mice per group; right). Dashed line represents freezing level of control mice (48.53). b, Average dendritic spine density in early AD mice treated with anisomycin after LTP induction (n = 4810 spines) was decreased compared to saline treated AD mice (n = 6242 spines, n = 4 mice per group). Dashed line represents spine density of control mice (1.21). Statistical comparisons are performed using unpaired t tests; *P < 0.05. Data are presented as mean ± SEM.