Table 1.

Rate constants obtained from global fit of kinetic data to mechanism in Fig. 5c that allows complete folding of Im7 while bound to Spy

	Rate constanta (s−1 or M−1s−1)
kUI	1610 ± 210
kIU	1940 ± 180
kIN	286 ± 23
kNI	0.99 ± 0.01
k1	1.4 ± 0.2 × 107
k−1	65 ± 14
k2	1.7 ± 0.2 × 107
k−2	79 ± 17
k3	3.3 ± 0.4 × 107
k−3	1000b
k4	51 ± 12
k−4	62 ± 11
k5	10.1 ± 2.1
k−5	0.23 ± 0.01

^aValues in 0.7 M urea. Determined by global analysis of all data (Supplementary Fig. 7). Values reported are the mean ± s.e. of the fit.

^bFixed at 1000 s⁻¹.