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. 2016 Apr 27;11(4):e0154539. doi: 10.1371/journal.pone.0154539

Table 2. Univariate analysis of survival outcomes in patients with SVZ-involved tumors.

Characteristic PFS OS
p HR 95% CI p HR 95% CI
Age ≥40 years 0.024 2.259 1.116–4.574 0.047 2.093 1.009–4.338
Sex (Male) 0.718 1.149 0.541–2.441 0.781 1.118 0.508–2.462
KPS <80 0.375 1.543 0.592–4.024 0.351 1.584 0.603–4.160
Volume ≥60 cm3 0.043 2.145 1.025–4.492 0.030 2.349 1.085–5.084
CS ≤30 mm 0.061 1.977 0.970–4.027 0.026 2.353 1.108–4.919
Regions contacting SVZ
 Frontal horn/others 0.850 1.070 0.528–2.171 0.700 1.156 0.554–2.409
<GTR 0.018 4.227 1.284–13.909 0.012 6.278 1.491–26.431
Radiation 0.504 0.747 0.318–1.756 0.333 0.652 0.275–1.548
Chemotherapy 0.752 1.139 0.508–2.553 0.618 1.232 0.544–2.789

CI, confidence interval; CS, the shortest distance from the tumor centroid to the edge of the lateral ventricles; GTR, gross total resection; HR, hazard ratio; KPS, Karnofsky Performance Status scale; OS, overall survival; PFS, progression-free survival; SVZ, subventricular zone.