Fig 1. A summary of each protocol within the five experiments.

The pen designations denote whether animals were housed within the same pen or separate pens and the letters may designate different pens across experiments. The number of feet qualified refers to the number of feet enrolled in each protocol that retained a wrap throughout the length of the study and did not receive topical or systemic antibiotics during the trial period. The induction rate is the percentage of feet that had a macroscopic lesion score of 7 or greater. The brackets denote statistical significance between groups with alpha = .05 and a correction for multiple testing.