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. 2016 Feb 6;17(1):20–26. doi: 10.1080/15384047.2015.1108484

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Figure 4. — KLF2 regulates c-myc expression in HCC cells (A) Relative mRNA levels of c-myc, p53, E2F1 and β-catenin in HuH7 cells overexpressing KLF2 or empty vector (EV). (B) Representative protein levels of c-myc in HuH7 cells. (C-D) Relative mRNA (C) and protein (D) levels of c-myc in HuH7 cells transfected with siRNA oligos targeting KLF2 or negative control (NC). (E-F) Relative mRNA levels of Cyclin A and Cyclin B1 in HuH7 cells with KLF2 overexpression (E) or knockdown (F). (G) A positive correlation between KLF2 and c-myc expression in 60 paired of HCC and normal liver tissues.