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Co-treatment with ABT-263 and vorinostat efficiently induces cell death in SCLC cells. Each SCLC cell line was treated with ABT-263 and/or vorinostat at the concentrations (µM) indicated in each graph. Cell viability was determined by WST-1 assay at 72 hours after treatment. Average values from triplicate samples are shown as representative of 2 independent experiments. Con, vehicle control; V (µM), vorinostat; ABT (µM), ABT-263. *P < 0.01 compared with control.
